Maximum tolerated dose studies are also done in clinical trials.
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In the Phase 1b trials shows the safety and pharmacokinetics that help decide what the maximum tolerated dose is.
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Also, how would you want to compare them-the number of pills, the maximum tolerated dose, or some other measure?
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In the first human study of BIBW 2992, the maximum tolerated dose in a two-week-on, two-week off schedule was 70 mg once-daily.
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This is generally defined by the range between the minimum effective dose ( MED ) and the maximum tolerated dose ( MTD ).
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Following inconclusive VEGF-C, circulating endothelial cells, and CD146 and CD34 / 133 counts, and a maximum tolerated dose has still not been established.
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Moreover, the first step in testing ordinary chemotherapy is to check for the maximum tolerated dose _ the amount that stops just short of killing the patient.
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In a phase I study of 25 patients with advanced solid tumours, BIBF 1120 showed a favourable safety and pharmacokinetic profile with a maximum tolerated dose of 250mg.
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In another phase I dose-escalation study, in 22 patients with advanced gynaecological malignancies, the maximum tolerated dose of BIBF 1120 twice-daily combined with paclitaxel and carboplatin was 200mg.
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A maximum tolerated dose of aldoxorubicin has been established at 3.5 times the MTD of doxorubicin, and studies have indicated increased response rates for patients with soft tissue sarcomas.
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